Analytics - Discovery-First Solutions

The Right System Starts with the Right Challenge.

Most chromatography providers start with a catalog. SYKAM starts with your goal. Our discovery approach begins with a conversation — scientist to scientist — to understand your samples, analytes, throughput, and compliance needs. Then we build precisely what your research requires.
Because SYKAM designs and manufactures every component in-house, from pump heads to columns, performance from the first injection isn’t a promise — it’s the result.

Methodology

Discovery Process

Four steps from your challenge to a delivered, supported system.

Step 1: LISTEN

We Study Your Application — Our specialists learn your sample types, analyte targets, detection limits, throughput demands, and regulatory standards. Whether you're profiling amino acids in neonatal blood, monitoring bromate at sub-ppb levels in drinking water, or characterizing collagen hydrolysates — we learn the science behind your need before we discuss hardware.

Step 2: CONFIGURE

We Design the Optimal System — With your requirements mapped, we select the ideal combination of instrumentation, separation chemistry, and detection. The S 433 with PHS-extended method for 53+ amino acids. The S 150 with the right suppression mode for your IC matrix. Every system is configured — not just assembled.

Step 3: CUSTOMIZE

We Adapt to Your Exact Specifications — Because SYKAM manufactures every critical component in-house, we can modify where others cannot. Different flow cell volumes. Specialized valve configurations. Custom ChromStar interfaces for LIMS integration. PEEK biocompatible flow paths. We engineer these in the same facility where your system is built.

Step 4: DELIVER & SUPPORT

We Stand Behind Every Result — Your system ships fully tested and qualified. But our partnership doesn't end at installation. Method validation support, operator training, ongoing application consulting, and direct access to the specialists who designed your system. When your needs evolve, we're already positioned to adapt.

Where Analytical Insight Meets Engineering Excellence

Amino Acid Analytics (S 433 / S 633)

The S 433 combines classical ion-exchange chromatography with HPLC automation for amino acid quantification at 10 picomole sensitivity — with validated linearity from 10 pM to 10 nM. The extended standard method resolves more than 50 amino acids and metabolites in a single run. Features: quaternary pump (up to 350 bar), automated injector (120 vials, cooled), column thermostat (5–85°C), high-temp ninhydrin reactor (185°C), dual-wavelength detection at 440/570 nm. 100% inert wetted materials (PEEK, PTFE, PVDF). Complete consumables ecosystem: LCA columns, Na/Li-citrate buffers, certified calibration standards. ChromStar 7 with Amino Acid Plugin for automated peak ID, calibration, and GLP-compliant reporting.

Ion Chromatography (S 150 / S 155)

Sykam IC systems enable precise separation and quantification of anions, cations, organic acids, and transition metals. Unlike most systems, Sykam ICs analyze anions, cations, and transition metals via automated valve switching. Trace detection down to 1 µg/L with automatic pre-concentration. Proprietary Auto-Suppressor eliminates costly cartridge replacements. Conductivity detection: 20 nS/cm–20,000 µS/cm. Flexible multi-detection: suppressed conductivity, UV/Vis at 220 nm, or PAR post-column derivatization for metals. Thermostated column oven (40–70°C). Modular and scalable — add cation, transition metal, or pre-concentration modules as needs evolve.

HPLC Columns (PEEK & Stainless Steel)

Sykam develops its own stationary phases, packs its own columns, formulates its own eluents, and validates complete separations on its own instruments. IC columns: SYK A 01 nG anion exchange (3 × 150 mm), resolves 10 anions, validated 12-point linearity. AA columns: LCA K06/Na (hydrolysate < 60 min), LCA K07/Li (physiological 50+ compounds < 120 min). Preparative PEEK: CNC-machined from solid natural PEEK, 50–70 mm ID, pressure-tested to 150 bar, acid/base stable. Guard columns and pre-wash columns for extended lifetime.

Custom Method Development

When standard methods don't fit, our specialists develop and validate custom separations. Buffer composition, pH, ionic strength, temperature profiles, gradient timing, detection wavelengths — all optimized for your acceptance criteria. Recent examples: resolving hydroxyproline and DOPA under Na-buffer conditions; extended physiological screens including 3-hydroxykynurenine, kynurenine, and aminoethylcysteine; multi-column IC for common anions plus trace disinfection byproducts. Complete SOPs, calibration standards, and consumables delivered with every method.

High Precision & Qualification

Systems ship with IQ/OQ protocols. Baseline stability < 5.0 mV drift (440/570 nm). Flow rate precision < 1.0% RSD. Temperature accuracy ±0.1°C (column oven), ±2°C (reactor). Linearity ≥ 0.999. ChromStar 7: role-based user admin, electronic signatures, complete audit trails, CFR 21 Part 11 compliance support. Designed to pass audit — not just meet minimum compliance.